脑功能基因组学教育部重点实验室
Key Laboratory of Brain Functional Genomics, Ministry of Education

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李晓涛 博士 蛋白质降解研究

发布日期:2016-10-25 浏览次数: 作者:

李晓涛 博士 蛋白质降解研究

脑功能基因组学教育部重点实验室PI
生命科学学院 教授
办公电话:021-54345018
Email: xiaotaol@gmail.com

 

 

研究方向
REGγ蛋白酶体的功能、调控、及其介导蛋白质降解的分子机制。

 

个人简历
1989      重庆医科大学, M.D
1989-1992 重庆医科大学附属第一医院,住院医师,主治医师
1992-1995 美国德克萨斯大学生物医学研究院 Research Fellowship
1995-2001 美国UT M.D. Anderson癌症中心Graduate Research Assistant。
2001      美国德克萨斯大学生物医学研究院, M.D. Anderson癌症中心Ph.D.
2001-2005  美国Baylor医学院, Postdoctoral Associate。
2005-2006  美国Baylor医学院, Instructor.
2006-2007.8月 美国Baylor医学院, Assistant Professor.
2007.8月 至今 华东师范大学,教授

 

学术任职/人才获奖
Oxidative Medicine and Cellular Longevity杂志   编委
Annals of Hematology & Oncology 杂志        编委
上海生化与分子生物学学会               理事

 

代表性成果

  1. Ji LXu J1, Liu JAmjad AZhang KLiu QZhou LXiao JLi X*., (2015), Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway. J Biol Chem. ;290(18):11729 -40.(影响因子:4.573)
  2. Li L, Dang Y, Zhang J, Yan W, Zhai W, Chen H, Li K, Tong L, Gao X, Amjad A, Ji L, Jing T, Jiang Z, Shi K, Yao L, Song D, Liu T, Yang X, Yang C, Cai X, Xu W, Huang Q, He J, Liu J, Chen T, Moses RE, Fu J, Xiao J, Li X*.,(2015), REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway.(in press)
  3. Li X*, Moses RE, Jin J, Cao W, Caulin C.,(2014), Stresses, aging, and age-related disorders. Oxid Med Cell Longev. 2014;2014:320564.(影响因子:3.516)
  4. Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Liu M, Yi Z, Xiao J, Li X*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014 Feb 20; 72C: 28-38. (影响因子:5.166)
  5. Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H. Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy. 2013 Aug 13;9 (10).(影响因子:12.042)
  6. Ali A,  Wang Z,  Ji L, Liu J, Li L, Yang Y, Wang Y, Zhou L,  Guo L, Wang H, Chen J, Caulin C, Myers JN, Fu J, Xiao J, Zhang B, Li X*. WT-p53/TGF-β signaling and mutant-p53 differentially regulates REGγ to target ubiquitin/ATP-independent REGγ-proteasome pathway during cancer progression. Nature Communication 2013 4:2667 (影响因子:10.015)
  7. Dong S, Jia C, Zhang S, Fan G, Xiao W, Shan P, Sun L, Li L, Zheng Y, Liu J, Li Y, Wei H, Hu C, Zhang W, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X* and Wang C* The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism 2013 Sep 3;18(3):380-91. (影响因子:17.3)
  8. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X*. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. (影响因子:9.737)
  9. Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B, Li X*. Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions. J Biol Chem. 2013 Jun 7;288(23):16567-78 (影响因子:4.651)
  10. Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ, Ramsay K, Kobelke SJ, Li X, Hatchell EC, Payne C, Giles KM, Messineo A, Gatignol A, Lanz RB, O'Malley BW, Leedman PJ. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6536-41. (影响因子:9.737)
  11. Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Li X*. (2012).  REGgamma is associated with multiple oncogenic pathways in human cancers. BMC Cancer. Feb 23; 12(1):75. (影响因子:3.333)
  12. Wu Y, Wang L, Zhou P, Wang G, Li X*. (2011).  Regulation of REGg cellular distribution and function by SUMO modification. Cell Research.  2011 May; 21(5):807-16. (影响因子:10.526)
  13. Gao G, Wong J, Zhang J, Mao I, Shravah J, Wu Y, Xiao A, Li X*, Luo H. (2010). Proteasome Activator REGg Enhances Coxsackieviral Infection via Facilitating p53 Degradation. J. Virol. 84 (21): 11056-11066. (影响因子:5.076)
  14. Liu J, Yu G., Zhao P., Wang C., Luo H., Long W., Wang Y., Zhao Y., Tsai M., O'Malley B.W. and Li X*. (2010).  REGγ modulates p53 activity by regulating its cellular localization. J. Cell Science. 123 (pt23): 4076-84.(影响因子:5.877)
  15. Yu G, Zhao Y, He J, Mukherjee A, Mao CA, Li M, and Li X*. (2008). Comparative analysis of REGγ expression augurs functional implication. J. Mol. Cell. Biol. Aug; 2(4):192-8.(影响因子:7.308)
  16. Ivy Mao, Jian Liu, Li X*, Honglin Luo. (2008). REGg, A Proteasome Activator and Beyond? Cell and Mol Life Sci. Dec;65(24):3971-80.(影响因子:5.615)
  17. Li X*, Larbi Amazit, Weiweng Long, David M. Lonard, John J. Monaco and
  18. O’Malley B.W. (2007). Proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol. Cell, 26,  831-842.(影响因子:15.28)
  19. Li X*., Lonard D., Jung S.Y., Malovannaya A., Feng Q., Qin J., Tsai S. Y., Tsai M-J., and O’Malley B.W. (2006).  The SRC-3/AIB1 coactivator is degraded in an ubiquitin- and ATP-independent manner by the REGgamm-proteasome  Cell. 124, 381-392.(影响因子:31.957)

 

 

 

 

 

 

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