"Normal and abnormal inductions of synaptic plasticity in rodent prefrontal cortex: possible roles in executive cognitive function"-Satoru Otani(University of Pierre and Marie Curie–Paris 6)

时间： 2010年6月11日10:00-11:30

地点：理科大楼A-510

报告题目：Normal and abnormal inductions of synaptic plasticity in rodent prefrontal cortex: possible roles in executive cognitive function

报告人：大谷悟 博士 University of Pierre and Marie Curie–Paris 6

报告人简介：神经的可塑性，包括其在神经生理学，神经化学以及认知及行为学等不同领域中的作用。目前的研究主要关注大脑学习和记忆功能的突触模型：长时程增强（）及长时程减弱。以对认知和学习记忆最为关键的脑区前额叶及海马为研究对象，利用电生理及化学药理学等方法，探讨了许多蛋白及分子，如氨基酸受体，胞质钙离子，胞内第二信使及多种蛋白合成酶对突触可塑性的影响。现期主要对大小鼠大脑前额叶的突触可塑性及儿茶酚安，如多巴胺，去甲肾上腺素等对其的调控，进行在体及离体的电生理研究，同时配合相关的行为学及生物化学检测。

报告简介：It is increasingly clear that dysregulation of neuroplasticity in the prefrontal cortex (PFC) may underlie cognitive abnormalities seen in certain psychiatric disorders such as schizophrenia and drug addiction. Using rodent in vitro and in vivo model systems, we have been studying synaptic plasticity in the PFC, i.e. long-term potentiation (LTP) and long-term depression (LTD), under various experimental conditions to gain insights into functional and dysfunctional neuroplasticity regulations in the PFC and their possible involvement in executive cognitive function. In this seminar, I will first show how the fast phasic and background tonic dopamine signals regulate normal and abnormal inductions of synaptic plasticity in rat PFC, and propose a mechanistic basis for pathogenesis of schizophrenia cognitive symptom. I will then present our more recent data on the regulatory role of dopamine transporters in synaptic plasticity in the PFC, which may be involved in behavioral rigidity as seen in drug addiction. Third, I will present our in vivo results in which the hippocampus-PFC monosynaptic connection and PFC-dependent cognition are profoundly modified by acute and chronic injections of non-competitive NMDA receptor antagonist MK801, a leading animal model of schizophrenia. Thus, in this seminar, I will present our cutting-edge knowledge obtained in several different model systems, in order to provide a global and comprehensive idea on the possible relation between normal/abnormal plasticity inductions in the PFC and changes of executive cognitive function.