"Working memory network sequences and neuropathological dynamics"Mark bordner 博士（美国MIND研究所）-2012.11.4

时间：2012年11月4日 13:30

地点：理科大楼A510

报告题目：Working memory network sequences and neuropathological dynamics

报告人：Mark bordner 博士 美国MIND研究所

报告人简介：Ph.d本科毕业于美国匹兹堡大学，加州大学洛杉矶分校获得博士学位。曾在加州大学洛杉矶分校精神病学和生物行为科学系，加州大学埃文分校物理系任职，现担任美国MIND研究所所长以及匹兹堡大学数学系和约翰霍普金斯神经外科系兼职教授职务。研究方向：包括神经网络的数学模型、工作记忆数学模型的建立，以及研究癫痫等神经疾病的机制。

报告简介：Persistent activation of neuronal populations in recurrent networks of cortico-cortical connections has been implicated as the substrate of working memory.   In addition to persistent activation of neuronal populations, temporal patterns of activity which repeat above chance levels in the brain have been reported experimentally, and this is thought to subserve functions such as movement, speech and rhythms.   A biologically plausible model of working memory is presented incorporating densely interconnected excitatory neurons and asymmetric Hebbian plasticity which reproduces the persistent activity of neuronal populations observed during working memory in the cortex.  The model is also capable of learning and reproducing complex sequence activity from external stimuli with implications for working memory oscillations and rhythm generation.    It will then be examined how specific changes in the architecture or parameters of the working memory network (e.g. reductions in network inhibition) lead to dynamics which may be associated with different neuropathologies including epilepsy, schizophrenia and obsessive compulsive disorders.  It will be shown how these different pathological dynamics may arise from similar or the same mechanisms acting in the recurrent working memory networks.