"Neuronal transporters regulate neurotransmitter supply and the vesicle cycle at inhibitory synapses "Stéphane Supplisson Ph.D -2016.4.8
时间: 2016年4月8日 上午10:00 am
地点： 中北校区 脑功能基因组学研究所一楼会议室
报告题目：Neuronal transporters regulate neurotransmitter supply and the vesicle cycle at inhibitory synapses
报告人： Stéphane Supplisson Ph.D
IBENS Neuroscience Section, Ecole normale supérieure de Paris
报告人简介： Stéphane Supplisson Ph.D, Co-leader of the Inhibitory Transmission team at IBENS.
Dr. Supplission got his Ph.D. in Cellular Physiology in University Paris XI and finished his postdoctoral training in UCLA Physiology Department in 1993. Then he started his research career as researcher in INSERM and was promoted as senior researcher in INSERM in 2001. Since 2008, he was Co-leader of the Inhibitory Transmission team at IBENS. His research interests were in Membrane Biology, Molecular Biophysics, transporters, electrophysiology, models, Neurobiology, Synaptic transmission and Synaptic vesicles. His research results were published on many first class academic Magazines (Neuron, PNAS, Journal of Neuroscience et.al ) and were awarded “Association Française contre les Myopathies” grants and Team “Fondation pour la Recherche Médicale” grant.
报告简介：The synchronized release of neurotransmitters by exocytosis requires their prior storage inside synaptic vesicles. This filling step of the vesicle cycle remains largely unexplored for physi-ology and vesicle imaging to investigate what happens when neurons run out of neuro-transmitter. At inhibitory synapses, the captures of glycine, GABA and its precursors by neuronal transporters are critical for maintaining vesicle filling and signaling during repetitive activity. Surprisingly, evidence suggests that the neurotransmitter cycle and the vesicle cycle are not independent but interplay with each other to match the synaptic release of GABA or glycine with available metabolic resource.