金鑫博士 神经环路、运动控制与脑机接口
脑功能基因组学教育部重点实验室副主任 PI
办公电话：021-62233533
Email: xjin@bio.ecnu.edu.cn
研究方向
神经环路；运动控制；脑机接口
教育经历
1998－2002 中国农业大学 学士
2002－2007 上海交通大学 博士
工作经历
2008－2011 美国国立卫生研究院 博士后
2012－2017 美国 索尔克生物研究所 助理教授
2018－2020 美国 索尔克生物研究所 副教授
2021－至今 华东师范大学特聘教授、运动控制与疾病研究中心主任
个人简介
华东师范大学运动控制与疾病研究中心教授、主任，脑功能基因组学教育部重点实验室研究员。2002年获中国农业大学学士学位，2007年获上海交通大学博士学位，2008-2011年在美国国立卫生研究院从事博士后研究。2012年起任索尔克生物研究所助理教授，2018年起任索尔克生物研究所副教授，2021年全职回国加入华东师范大学任特聘教授。主要采用分子，电生理，光学成像，光遗传和行为学手段研究大脑基底节神经环路与运动控制，及其在运动和精神疾病中的机理。研究工作曾获得美国国立卫生研究院拉特里奖，美国神经科学学会格鲁伯国际研究奖和麦克奈特记忆与认知障碍奖等。
代表性研究论文:
1. Cook JR, Li H, Nguyen B, Huang HH, Mahdavian P, Kirchgessner MA, Strassmann P, Engelhardt M, Callaway EM, Jin X (2022) Secondary auditory cortex mediates a sensorimotor mechanism for action timing. Nature Neuroscience 25(3): 330-344.
2. Zhang Z, Zhou J, Tan P, Pang Y, Rivkin AC, Kirchgessner MA, Williams E, Lee CT, Liu H, Franklin AD, Miyazaki PA, Bartlett A, Aldridge AI, Vu M, Boggeman L, Fitzpatrick C, Nery JR, Castanon RG, Rashid M, Jacobs MW, Ito-Cole T, O'Connor C, Pinto-Duartec A, Dominguez B, Smith JB, Niu SY, Lee KF, Jin X, Mukamel EA, Behrens MM, Ecker JR, Callaway EM (2021) Epigenomic diversity of cortical projection neurons in the mouse brain. Nature 598(7879): 167-173.
3. Hollon NG, Williams EW, Howard CD, Li H, Traut TI, Jin X (2021) Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors. Current Biology 31(23): 5350-5363.
4. Zell V, Steinkellner T, Hollon NG, Warlow SM, Souter E, Faget L, Hunker AC, Jin X, Zweifel LS, Hnasko TS (2020) VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release. Neuron 107(5): 864-873.
5. Hollon NG, Jin X (2020) Neural implementation of behavioral hierarchy. Neuron 105(3): 402-404.
6. Aoki S, Smith JB, Li H, Yan X, Igarashi M, Coulon P, Wickens JR, Ruigrok TJ, Jin X (2019) An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway. eLife 8: e49995.
7. Geddes CE, Li H, Jin X (2018) Optogenetic editing reveals the hierarchical organization of learned action sequences. Cell 174(1): 32-43.
8. Klug JR, Engelhardt MD, Cadman CN, Li H, Smith JB, Ayala S, Williams EW, Hoffman H, Jin X (2018) Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions. eLife 7: e35657.
9. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH (2018) An in vivo model of functional and vascularized human brain organoids. Nature Biotechnology 36(5): 432-441.
10. Howard CD, Li H, Geddes CE, Jin X (2017) Dynamic nigrostriatal dopamine biases action selection. Neuron 93(6): 1436-1450.
11. Smith JB, Klug JR, Ross DL, Howard CD, Hollon NG, Ko VI, Hoffman H, Callaway EM, Gerfen CR, Jin X (2016) Genetic-based dissection unveils the inputs and outputs of striatal patch and matrix compartments. Neuron 91(5): 1069-1084.
12. Tecuapetla F, Jin X, Lima SQ, Costa RM (2016) Complementary contributions of striatal projection pathways to action initiation and execution. Cell 166(3): 703-715.
13. Amin ND, Bai G, Klug JR, Bonanomi D, Pankratz MT, Gifford WD, Hinckley CA, Sternfeld MJ, Driscoll SP, Dominguez B, Lee KF, Jin X, Pfaff SL (2015) Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science 350(6267): 1525-1529.
14. Santos FJ, Oliveira RF, Jin X, Costa RM (2015) Corticostriatal dynamics encode the refinement of specific behavioral variability during skill learning. eLife 4: e09423.
15. Jin X, Costa RM (2015) Shaping action sequences in basal ganglia circuits. Current Opinion in Neurobiology 33: 188-196.
16. Jin X, Tecuapetla F, Costa RM (2014) Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nature Neuroscience 17(3): 423-430.
17. Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM (2013) Concurrent activation of striatal direct and indirect pathways during action initiation. Nature 494(7436): 238-242.
18. French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM (2012) An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Molecular Psychiatry 17(11): 1770-1085.
19. Koralek AC*, Jin X*, Long JD, Costa RM, Carmena JM (2012) Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature 483(7389): 331-335. (* Co-first authors)
20. Jin X, Costa RM (2010) Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature 466(7305): 457-462.